| Cat.No. | Name | Information |
|---|---|---|
| M2030 | Apremilast | Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM. |
| M6804 | IBMX | IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. |
| M10435 | Difamilast | Difamilast (OPA-15406) is a topical, highly selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor. |
| M10179 | Vesnarinone | Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity. |
| M9882 | Roflumilast N-oxide | Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. |
| M9679 | CP671305 | CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities. |
| M9347 | ITI-214 phosphate | ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. |
| M8863 | YM 976 | Phosphodiesterase type IV (PDE4) inhibitor. |
| M8344 | MBCQ | MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V; IC50=19 nM. |
| M7630 | Butein | Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4. Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells. Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Butein is a SIRT1 activator. |
| M7429 | Trequinsin hydrochloride | Trequinsin hydrochloride is a extremely potent inhibitor of PDE3. |
| M6604 | Cilostamide | Cilostamide is a pDE3 inhibitor. |
| M6560 | Carbazeran citrate | Carbazeran citrate is a aldehyde oxidase substrate; PDE inhibitor. |
| M6287 | GLPG1690 | Ziritaxestat (GLPG1690) is a first-in-class autotaxin (ATX) inhibitor, with IC50 of 131 nM and Ki of 15 nM. |
| M6153 | E6005 | RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM. |
| M6048 | Vardenafil HCl | Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction. |
| M6042 | Udenafil | Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction. |
| M6007 | Theophylline | Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist. |
| M5960 | Sildenafil Mesylate | Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5. |
| M5959 | Sildenafil | Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM. |
| M5939 | Rolipram | A selective inhibitor of PDE4, Rolipram, inhibits immunopurified PDE4B and PDE4D activity with IC50 of 130 nM and 240 nM, respectively. It has anti-inflammatory activity. Rolipram also increased cAMP levels and activated PKA, which in turn increased proteasome activity and inhibited tau aggregation. |
| M5833 | Olprinone | Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. |
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