| Cat.No. | Name | Information |
|---|---|---|
| M6804 | IBMX | IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. |
| M2030 | Apremilast | Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM. |
| M58458 | MR-L2 | MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM. |
| M49399 | ATX inhibitor 1 | ATX inhibitor 1 is a potent ATX (IC50=1.23 nM, FS-3; 2.18 nM, bis-pNPP) inhibitor. |
| M30017 | Zaprinast | Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs). Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects. |
| M29915 | DNMDP | DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity. |
| M28851 | Cudetaxestat | Cudetaxestat (BLD-0409) is a potent and orally active autotaxin (ATX) inhibitor. |
| M25404 | Nerandomilast (BI 1015550) | Nerandomilast (BI 1015550) is a novel, orally active phosphodiesterase 4B (PDE4B) inhibitor (IC50 = 7.2 nM) with anti-fibrotic and anti-inflammatory effects. |
| M21175 | BIO-32546 | Compound BIO-32546 is a potent (IC50=1 nM), selective, orally administered, non-zinc-binding reversible inhibitor of autophagy (ATX). |
| M21149 | FPFT-2216 | FPFT-2216 is a ''molecular glue'' compound that degrades phosphatidiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) and casein kinase 1α (CK1α). It can be used for cancer and inflammatory disease research. |
| M21089 | Mirodenafil | Mirodenafil is a newly developed oral type 5 phosphodiesterase inhibitor. mirodenafil is a modulator of the glucocorticoid receptor (GR). mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating the expression of Dkk1. mirodenafil can be used to study erectile dysfunction (ED), Alzheimer's disease (AD) and systemic sclerosis (SSc). Mirodenafil can be used to study erectile dysfunction (ED), Alzheimer's disease (AD), and systemic sclerosis (SSc). |
| M20847 | Ro 20-1724 | Ro 20-1724 is a potent inhibitor of PDE IV with Ki value of 3.1 μM and a potent gastric secretagogues. |
| M14506 | PF-04957325 | PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. |
| M14505 | PF-04447943 | PF-04447943 is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM). |
| M14499 | (R)-(-)-Rolipram | (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
| M11547 | Ensifentrine | Ensifentrine (RPL-554) is an inhaled, pioneering dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50 of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activity and can be used to study chronic obstructive pulmonary disease (COPD). |
| M11451 | Autotaxin modulator 1 | Autotaxin Modulator 1 is an Autotaxin (ATX) inhibitor of Autotaxin (ATX). Autotaxin Modulator 1 is expected to be used for demyelination caused by injury or disease, as well as for the study of proliferative diseases such as tumors. |
| M11109 | 3-O-Methylquercetin | 3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin (3-MQ) exhibits IC50 values of 31.9 μM， 86.9 μM， 18.6 μM and 1.6 μM for PDE1, PDE5, PDE2 and PDE4, respectively. |
| M10631 | Enpp-1-IN-1 | Enpp-1-IN-1, also known as MV 658, is a Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitor. |
| M10517 | D159687 | D159687 is a selective negative allosteric modulator (NAM) of PDE4D. |
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