PDE Phosphodiesterase

Cat.No.	Name	Information
M2030	Apremilast	Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.
M6804	IBMX	IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively.
M5174	Icariin	Icariin is a flavonol glycoside. Icariin inhibited PDE5 and PDE4 activity with IC50 of 432 nM and 73.50 μM, respectively. Icariin is also a PPARα activator. Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoiesis, immunity and bone metabolism.
M5060	Propentofylline	Adamantane derivatives, processes for their preparation and pharmaceutical composition containing them.
M4964	HA130	HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM.
M4851	TAK-063	TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM.
M4397	Fraxin	Fraxin is a glucoside of fraxetin, an O-methylated coumarin. Fraxin shows its antioxidative effect through inhibition of cyclo AMP phosphodiesterase enzyme. Fraxin was administered orally to rats to investigate its metabolism.
M3700	PF8380	Pf-8380 is a potent autotaxin inhibitor with IC50 of 2.8 nM and 101 nM in in vitro enzyme assay and human whole blood cell assay, respectively.
M3587	Dyphylline	Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.
M3566	Vardenafil hydrochloride Trihydrate	Vardenafil hydrochloride Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
M3557	Dipyridamole	Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
M3473	Tadalafil	Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM.
M3447	PF-2545920	PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.
M3437	Cilomilast	Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
M3434	Pimobendan	Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
M3394	Deltarasin	Deltarasin is a novel small molecule which inhibits the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling.
M3375	S-(+)-Rolipram	S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
M3337	Milrinone	Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE.
M3259	Irsogladine	Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
M2923	Pentoxifylline	Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.
M2764	Ibudilast	Ibudilast is a potent PDE4 inhibitor for PDE4A with IC50 of 54 nM.
M2702	Flavoxate hydrochloride	Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM.

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PDE Phosphodiesterase

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