| Cat.No. | Name | Information |
|---|---|---|
| M2030 | Apremilast | Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. |
| M6804 | IBMX | IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. |
| M3700 | PF8380 | Pf-8380 is a potent autotaxin inhibitor with IC50 of 2.8 nM and 101 nM in in vitro enzyme assay and human whole blood cell assay, respectively. |
| M3588 | Aminophylline | Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist. |
| M3587 | Dyphylline | Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects. |
| M3566 | Vardenafil hydrochloride Trihydrate | Vardenafil hydrochloride Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
| M3473 | Tadalafil | Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM. |
| M3447 | PF-2545920 | PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE. |
| M3437 | Cilomilast | Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
| M3434 | Pimobendan | Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. |
| M3394 | Deltarasin | Deltarasin is a novel small molecule which inhibits the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling. |
| M3375 | S-(+)-Rolipram | S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
| M3337 | Milrinone | Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE. |
| M3259 | Irsogladine | Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding. |
| M2923 | Pentoxifylline | Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. |
| M2764 | Ibudilast | Ibudilast is a potent PDE4 inhibitor for PDE4A with IC50 of 54 nM. |
| M2702 | Flavoxate hydrochloride | Flavoxate is a muscarinic AChR antagonist with IC50 of 12.2 μM. |
| M2651 | Doxofylline | Doxofylline is a xanthine derivative and a phosphodiesterase (PDE) inhibitor that can be used in asthma-related studies. |
| M2410 | Avanafil | Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs. |
| M2395 | Anagrelide hydrochloride | Anagrelide HCl is a primary thrombocytopenia compound. It has anti-cyclic adenylate phosphodiesterase activity and inhibits platelet aggregation in both humans and animals. Anagrelide works by inhibiting megakaryocytes from maturing into platelets. |
| M2337 | AN2728 | AN2728 is a topical anti-inflammatory product candidate for the treatment of psoriasis and atopic dermatitis. |
| M2286 | Sildenafil citrate | Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). |
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