Free shipping on all orders over $ 500

Tadalafil

Cat. No. M3473
Tadalafil Structure
Synonym:

IC351

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 31.5  USD35 In stock
50mg USD 72  USD80 In stock
100mg USD 112.5  USD125 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Tadalafil (Cialis) is a PDE inhibitor. Tadalafil (Cialis), which has demonstrated a high level of selectivity for PDE5 over the other phosphodiesterases, has shown efficacy in improving erectile function and sexual satisfaction in phase III trials. PDE11A3, PDE11A2, and PDE11A1, which contain progressively shorter N-termini, were more sensitive than PDE11A4 to inhibition by Tadalafil (Cialis).

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Sham-operated rats
Formulation Saline
Dosages 2 mg/kg
Administration Orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 389.4
Formula C22H19N3O4
CAS Number 171596-29-5
Purity >99%
Solubility DMSO 48 mg/mL
Storage at -20°C
Related PDE Products
Vesnarinone

Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity.

Roflumilast N-oxide

Roflumilast N-oxide is a phosphodiesterase 4 inhibitor.

CP671305

CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities.

ITI-214 phosphate

ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).

IBMX

IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tadalafil, IC351 supplier, PDE, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.