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Milrinone

Cat. No. M3337
Milrinone Structure
Synonym:

Win 47203

Size Price Availability Quantity
50mg USD 58  USD58 In stock
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Milrinone (Primacor) is a a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 uM for the inhibition of FIII PDE. It potentiates the effect of cyclic adenosine monophosphate (cAMP). It also enhances relaxation of the left ventricle by increasing Ca2+-ATPase activity on the cardiac sarcoplasmic reticulum. This increases calcium ion uptake.It has positive inotropic, vasodilating and minimal chronotropic effects. It is used in the management of heart failure only when conventional treatment with vasodilators and diuretics has proven insufficient. This is due to the potentially fatal adverse effects of milrinone, including ventricular arrhythmias.

Chemical Information
Molecular Weight 211.22
Formula C12H9N3O
CAS Number 78415-72-2
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rebecca Mathew, et al. Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock

[2] Yasser B Abulhasan, et al. Milrinone for refractory cerebral vasospasm with delayed cerebral ischemia

[3] Amna Qasim, et al. Milrinone Use in Persistent Pulmonary Hypertension of the Newborn

[4] Tyler C Lewis, et al. Comparative Effectiveness and Safety Between Milrinone or Dobutamine as Initial Inotrope Therapy in Cardiogenic Shock

[5] Luke Yong Zheng Chong, et al. Milrinone Dosing and a Culture of Caution in Clinical Practice

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  Catalog
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