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Vardenafil hydrochloride Trihydrate

Cat. No. M3566
Vardenafil hydrochloride Trihydrate Structure
Synonym:

BAY38-9456

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 75  USD75 In stock
25mg USD 150  USD150 In stock
50mg USD 220  USD220 In stock
100mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Vardenafil is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. Vardenafil’s indications and contra-indications are the same as with other PDE5 inhibitors. Structurally, the difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom’s position and the change of sildenafil’s piperazine ring methyl group to an ethyl group. Chronic vardenafil treatment improves erectile function via structural maintenance of penile corpora cavernosa in rats with acute arteriogenic erectile dysfunction.

Chemical Information
Molecular Weight 579.11
Formula C23H32N6O4S.HCl.3H2O
CAS Number 330808-88-3
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Heba Samir Elama, et al. Utilization of a micellar matrix for simultaneous spectrofluorimetric estimation of alfuzosin hydrochloride and vardenafil hydrochloride

[2] Khaled El-Refai, et al. Dual-purpose vardenafil hydrochloride/dapoxetine hydrochloride orodispersible tablets: in vitro formulation/evaluation, stability study and in vivo comparative pharmacokinetic study in healthy human subjects

[3] Abdelkader E Ashour, et al. Vardenafil dihydrochloride

[4] Jay M Young. Vardenafil

[5] Douglas Ormrod, et al. Vardenafil

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  Catalog
Abmole Inhibitor Catalog




Keywords: Vardenafil hydrochloride Trihydrate, BAY38-9456 supplier, PDE, inhibitors, activators


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