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Rolipram

Cat. No. M5939
Rolipram Structure
Synonym:

ZK-62711, SB 95952

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 44.1  USD49 In stock
10mg USD 36  USD40 In stock
50mg USD 58.5  USD65 In stock
100mg USD 81  USD90 In stock
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Quality Control
Biological Activity

The PDE4 selective inhibitor, rolipram, inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent. Rolipram increases phosphorylation of cAMP-response-element-binding protein (CREB) in U937 cells in a dose-dependent fashion, which implies the presence of both high affinity (IC50 approx. 1 nM) and low affinity (IC50 approx. 120 nM) components. Rolipram dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK in a simple monotonic fashion with an IC50 of approx. 290 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 275.34
Formula C16H21NO3
CAS Number 61413-54-5
Purity 99.1%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

Effects of rolipram and zaprinast on learning and memory in the Morris water maze and radial arm maze tests in naive mice.
Akar F, et al. Drug Res (Stuttg). 2015 Feb;65(2):86-90. PMID: 24764251.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Rolipram, ZK-62711, SB 95952 supplier, PDE, inhibitors

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