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S-(+)-Rolipram

Cat. No. M3375

All AbMole products are for research use only, cannot be used for human consumption.

S-(+)-Rolipram Structure
Synonym:

(+)-Rolipram; (S)-Rolipram

Size Price Availability Quantity
10mg USD 110  USD110 In stock
50mg USD 410  USD410 In stock
100mg USD 710  USD710 In stock
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Biological Activity

S- (+)-Rolipram is a less active enantiomer of the PDE4 inhibitor with an EC50 of 1.0 uM. It is an anti-inflammatory drug. Rolipram is being studied as a possible alternative to current antidepressants. Recent studies show that rolipram may have antipsychotic effects. It displays activity 10-fold less than R-rolipram at inhibition of PDE IV. It inhibits antigen-induced contraction of guinea-pig colonic smooth muscle.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Hartley guinea pigs
Formulation S-(+)-Rolipram is dissolved in 100% PEG at an appropriate concentration.
Dosages 1 mL/kg
Administration Administered via i.v.
Chemical Information
Molecular Weight 275.34
Formula C16H21NO3
CAS Number 85416-73-5
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Shiqin Xiong, et al. IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

[2] Seyed Mohammad Nabavi, et al. Phosphodiesterase inhibitors say NO to Alzheimer's disease

[3] Mireille Lortie, et al. Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET

[4] Kam Leung. 4-(3-Cyclopentoxy-4-[ 11 C]methoxy-phenyl)pyrrolidin-2-one

[5] Christine A Parker, et al. Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4

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Keywords: S-(+)-Rolipram, (+)-Rolipram; (S)-Rolipram supplier, PDE, inhibitors, activators

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