Free shipping on all orders over $ 500

Sildenafil

Cat. No. M5959
Sildenafil  Structure
Synonym:

Revatio, UK-92480, Viagra

Size Price Availability Quantity
50mg USD 72  USD80 In stock
100mg USD 108  USD120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 474.58
Formula C22H30N6O4S
CAS Number 139755-83-2
Purity >98%
Solubility 14 mg/mL in water
Storage at -20°C
References

Sildenafil in pediatric pulmonary arterial hypertension.
Dhariwal AK, et al. J Postgrad Med. 2015 Jul-Sep;61(3):181-92. PMID: 26119438.

Related PDE Products
Vesnarinone

Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity.

Roflumilast N-oxide

Roflumilast N-oxide is a phosphodiesterase 4 inhibitor.

CP671305

CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities.

ITI-214 phosphate

ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).

IBMX

IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sildenafil , Revatio, UK-92480, Viagra supplier, PDE, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.