| Cat.No. | Name | Information |
|---|---|---|
| M2030 | Apremilast | Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM. |
| M6804 | IBMX | IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. |
| M42562 | ATX inhibitor 18 | ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. |
| M42561 | Reticulol | Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. |
| M42560 | Nerandomilast dihydrate | Nerandomilast (BI 1015550) dihydrate is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. |
| M42559 | Theodrenaline hydrochloride | Theodrenaline hydrochloride is a cardiac stimulant, also acts as an anti-hypotensive agent together with Cafedrine. |
| M42558 | Enpp-1-IN-15 | Enpp-1-IN-15 is an Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (Enpp-1) Inhibitor, with a Ki value of 0.00586 nM. |
| M42557 | PDE4-IN-14 | PDE4-IN-14 is a PDE4 inhibitor that can be used in the study of PDE4-related diseases (such as inflammatory and immune diseases, cancer, and metabolic diseases, etc.). |
| M42556 | Enpp-1-IN-17 | Enpp-1-IN-17 is a potent ENPP1 inhibitor, with the inhibition constants (Ki values) toward cGAMP and ATP hydrolysis of 100 nM-1 μM and > 1 μM, respectively. |
| M42555 | Yonkenafil | Yonkenafil (Tunodafil), a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. |
| M42554 | Yonkenafil hydrochloride | Yonkenafil (Tunodafil) hydrochloride is a novel phosphodiesterase 5 (PDE5) inhibitor. |
| M39172 | Kushenol B | Kushenol B is an isoprenoid flavonoid isolated from S. flavescens, has antimicrobial, anti-inflammatory and antioxidant activities. Kushenol B has inhibitory activity against cAMP phosphodiesterase (PDE), with an IC50 of 31 µM. |
| M39171 | Mangostanol | Mangostanol ((+)-Mangostanol) is a polyoxygenated xanthone mangostanol, which can be isolated from the shell of Garcinia mangostana, and has inhibitory effect on cAMP phosphodiesterase (PDE). |
| M39170 | N-Desmethyl Sildenafil | N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. |
| M39169 | 5,7-Diacetoxy-8-methoxyflavone | 5,7-Diacetoxy-8-methoxyflavone is a natural product that could come from scutellaria genus plants. 5,7-Diacetoxy-8-methoxyflavone has inhibitory activity for cAMP phosphodiesterase. |
| M31401 | PAT-347 | PAT-347 is an Autotaxin (ATX) inhibitor. |
| M30839 | Mardepodect | Mardepodect (PF-2545920) is a potent, orally active and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over other PDEs. Mardepodect can cross the blood-brain barrier. |
| M30720 | Mirodenafil dihydrochloride | Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc). |
| M30648 | Anagrelide hydrochloride monohydrate | Anagrelide hydrochloride monohydrate is a imidazoquinazoline agent. Anagrelide hydrochloride monohydrate decreases the level of platelets in blood, prevents blood clots formation. Anagrelide hydrochloride monohydrate can be used for research of essential thrombocythaemia (ET) and thrombocythaemia associated with polycythaemia vera (PV). |
| M30534 | GSK356278 | GSK356278 is a potent, selective, orally bioavailable and brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory activity, and exhibits anxiolytic and cognition-enhancing effects. |
| M30483 | Anagrelide | Anagrelide, an inhibitor of phosphodiesterase type III (PDEIII) (IC50=36 nM), inhibits platelet production. Anagrelide, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide plays in the antithrombopoietic action. The platelet-lowering agent. |
| M30355 | Amrinone | Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent. |
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