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(R)-(-)-Rolipram

Cat. No. M14499
(R)-(-)-Rolipram Structure
Synonym:

(R)-Rolipram; (-)-Rolipram

Size Price Availability Quantity
10mg USD 120  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 275.34
Formula
CAS Number 85416-75-7
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

[1] Maarten Ooms, et al. [ 11 C]( R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice

[2] Miran Kenk, et al. PET measurements of cAMP-mediated phosphodiesterase-4 with (R)-[11C]rolipram

[3] Mireille Lortie, et al. Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET

[4] Kam Leung. 4-(3-Cyclopentoxy-4-[ 11 C]methoxy-phenyl)pyrrolidin-2-one

[5] Christine A Parker, et al. Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4

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  Catalog
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Keywords: (R)-(-)-Rolipram, (R)-Rolipram; (-)-Rolipram supplier, PDE, inhibitors

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