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Vesnarinone

Cat. No. M10179
Vesnarinone Structure
Synonym:

OPC-8212; Piteranometozine; Arkin

Size Price Availability Quantity
10mg USD 126  USD140 In stock
25mg USD 207  USD230 In stock
50mg USD 369  USD410 In stock
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Quality Control
  • Current batch:
  • Purity >97%
  • COA
  • MSDS
Biological Activity

Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 395.45
Formula C22H25N3O4
CAS Number 81840-15-5
Purity >97%
Solubility DMSO ≥ 10 mM
Storage at -20°C
References

Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein
Kentaro Hotta, et al. Mol Pharmacol. 2013 May;83(5):930-8. PMID: 23393163.

Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin
Minoru Inage, et al. Int J Biol Sci. 2009;5(4):304-10. PMID: 19381349.

Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line
Y Katayama, et al. J Pharmacol Exp Ther. 2000 Jul;294(1):339-46. PMID: 10871331.

Vesnarinone: a new inotropic agent for treating congestive heart failure
E Cavusoglu, et al. J Card Fail. 1995 Jun;1(3):249-57. PMID: 9420657.

Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure
A Matsumori, et al. Circulation. 1994 Mar;89(3):955-8. PMID: 8124835.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vesnarinone, OPC-8212; Piteranometozine; Arkin supplier, PDE, inhibitors

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