Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 10 mM|
Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein
Kentaro Hotta, et al. Mol Pharmacol. 2013 May;83(5):930-8. PMID: 23393163.
Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin
Minoru Inage, et al. Int J Biol Sci. 2009;5(4):304-10. PMID: 19381349.
Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line
Y Katayama, et al. J Pharmacol Exp Ther. 2000 Jul;294(1):339-46. PMID: 10871331.
Vesnarinone: a new inotropic agent for treating congestive heart failure
E Cavusoglu, et al. J Card Fail. 1995 Jun;1(3):249-57. PMID: 9420657.
Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure
A Matsumori, et al. Circulation. 1994 Mar;89(3):955-8. PMID: 8124835.
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