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Vesnarinone

Cat. No. M10179
Vesnarinone Structure
Synonym:

OPC-8212; Piteranometozine; Arkin

Size Price Availability Quantity
10mg USD 140  USD140 In stock
25mg USD 230  USD230 In stock
50mg USD 410  USD410 In stock
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Quality Control & Documentation
Biological Activity

Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.

Chemical Information
Molecular Weight 395.45
Formula C22H25N3O4
CAS Number 81840-15-5
Solubility (25°C) DMSO ≥ 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kentaro Hotta, et al. Mol Pharmacol. Vesnarinone suppresses TNFα mRNA expression by inhibiting valosin-containing protein

[2] Minoru Inage, et al. Int J Biol Sci. Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin

[3] Y Katayama, et al. J Pharmacol Exp Ther. Inhibitory effects of vesnarinone on cloned cardiac delayed rectifier K(+) channels expressed in a mammalian cell line

[4] E Cavusoglu, et al. J Card Fail. Vesnarinone: a new inotropic agent for treating congestive heart failure

[5] A Matsumori, et al. Circulation. Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure

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Keywords: Vesnarinone, OPC-8212; Piteranometozine; Arkin supplier, PDE, inhibitors, activators


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