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Roflumilast N-oxide

Cat. No. M9882
Roflumilast N-oxide Structure
Size Price Availability Quantity
10mg USD 108  USD120 In stock
25mg USD 189  USD210 In stock
50mg USD 315  USD350 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. Roflumilast N-Oxide in Combination with Formoterol Enhances the Antiinflammatory Effect of Dexamethasone in Airway Smooth Muscle Cells. Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 419.21
Formula C17H14Cl2F2N2O4
CAS Number 292135-78-5
Purity >99%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

Roflumilast n-oxide associated with PGE2 prevents the neutrophil elastase-induced production of chemokines by epithelial cells
Tatiana Victoni, et al. Int Immunopharmacol. 2016 Jan;30:1-8. PMID: 26610096.

Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro
Javier Milara, et al. COPD. 2015 Jun;12(3):320-31. PMID: 25207459.

The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice
S Vollert, et al. Diabetologia. 2012 Oct;55(10):2779-2788. PMID: 22790061.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Roflumilast N-oxide supplier, PDE, inhibitors

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