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Theophylline

Cat. No. M6007
Theophylline Structure
Synonym:

1,3-Dimethylxanthine; Theo-24

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 40  USD40 In stock
500mg USD 76  USD76 In stock
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Quality Control
Biological Activity

Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 180.16
Formula C7H8N4O2
CAS Number 58-55-9
Purity 100.00%
Solubility 21 mg/mL in DMSO
Storage at -20°C
References

[1] Pacifici GM, et al. Curr Pediatr Rev. Clinical pharmacology of theophylline in preterm infants: effects, metabolism and pharmacokinetics.

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Keywords: Theophylline, 1,3-Dimethylxanthine; Theo-24 supplier, PDE, inhibitors

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