DMOG (Dimethyloxaloylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.
Nanomaterials (Basel). 2022 Jan 3;12(1):163.
Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α
DMOG purchased from AbMole
 |
Source | Int J Biol Sci (2018). Figure 3. DMOG |
| Method | Western blot | |
| Cell Lines | BMSCs | |
| Concentrations | 0.5mM | |
| Incubation Time | 48 h | |
| Results | The number of surviving BMSCs cultured in normoxic condition was 8.3×10^3. The number of surviving cells number was 3.9×10^4 in the DMOG-treated group. |
| Molecular Weight | 175.14 |
| Formula | C6H9NO5 |
| CAS Number | 89464-63-1 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Jessica M Falcon, et al. DMOG Negatively Impacts Tissue Engineered Cartilage Development
| Related HIF Products |
|---|
| 3-Aminobenzoic acid
3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor. |
| Steppogenin
Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. |
| HIV-IN-7
Axl-IN-16 is a Axl inhibitor. |
| HIF-2α-IN-9
HIF-2α-IN-9 is an inhibitor ofHIF-2α. |
| PHD-IN-2
PHD-IN-2 is a PHD antagonist (IC50: < 5 nM). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
