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DMOG (Dimethyloxaloyl glycine) is an antagonist of α-ketoglutarate cofactor and a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo. DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG induces cell autophagy.
DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal. DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice.
Nanomaterials (Basel). 2022 Jan 3;12(1):163.
Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α
DMOG purchased from AbMole
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Source | Int J Biol Sci (2018). Figure 3. DMOG |
| Method | Western blot | |
| Cell Lines | BMSCs | |
| Concentrations | 0.5mM | |
| Incubation Time | 48 h | |
| Results | The number of surviving BMSCs cultured in normoxic condition was 8.3×10^3. The number of surviving cells number was 3.9×10^4 in the DMOG-treated group. |
| Molecular Weight | 175.14 |
| Formula | C6H9NO5 |
| CAS Number | 89464-63-1 |
| Solubility (25°C) | DMSO ≥ 70 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Jessica M Falcon, et al. DMOG Negatively Impacts Tissue Engineered Cartilage Development
| Related HIF Products |
|---|
| HIF-1α-IN-3
HIF-1α-IN-3 is a hypoxia-selective HIF-1α inhibitor. |
| HIF-2α-IN-2
HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor, has an IC50 of 16 nM in scintillation proximity assay (SPA). |
| PRLX-93936 dihydrochloride
PRLX-93936 dihydrochloride is a HIF-1α inhibitor with anticancer activity. |
| 3-Aminobenzoic acid
3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor. |
| Steppogenin
Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. |
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