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Paeoniflorin could activate PI3K/Akt signaling pathway to protect the PC12 cell injury induced by Aβ25-35.Paeoniflorin most likely contributes to the therapy for liver disease by exerting anti-inflammatory effects on HHSECs through blocking IL-8 secretion via downregulation of ERK1/2 and Akt.PF alleviates psoriatic skin lesions by inhibiting inflammation, which provides new insights into the immunomodulatory effect of PF in psoriasis treatment.Paeoniflorin pretreatment protects mice against Con A-induced liver injury via inhibition of several inflammatory mediators and, at least in part, by suppressing CD4(+), CD8(+) and NKT cell infiltration in liver. The beneficial effect of paeoniflorin may be related to the downregulation of TLR4 expression and the inhibition of NF-κB activation.Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α expression partly through mTOR pathway and paeoniflorin may be a potential therapeutic agent for liver fibrosis.
| Cell Experiment | |
|---|---|
| Cell lines | PC12 cells |
| Preparation method | Cell Viability Assessment Cell viability was measured using a quantitative colori-metric assay with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyl tetrazolium bromide (MTT) (Sigma-Aldrich, USA) as reported previously (Mosmann 1983). Briefly, cells were seeded into collagen I-coated 96-well plates at a density of 1*104 per well. At the completion of the 24-h treatment, 10 μL MTT solution (5 mg/mL) was added. Following incubation for 4 h at 37 ℃, 100 μL dimethyl sulfoxide (DMSO) was used to dissolve crystals. The absorbance was measured using a microplate reader (Bio-Rad, USA) and cell viability was expressed as a percentage of control value. |
| Concentrations | 0, 25, 50, 100, 200 and 400 μM |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Adult male Sprague-Dawley rats |
| Formulation | PBS, pH 7.5, 0.1 M at a concentration of 200 μg/μL |
| Dosages | 15 mg/kg and 30 mg/kg for 20 consecutive days |
| Administration | i.p. |
| Molecular Weight | 480.46 |
| Formula | C23H28O11 |
| CAS Number | 23180-57-6 |
| Form | Solid |
| Solubility (25°C) | Water > 80 mg/mL DMSO > 60 mg/mL |
| Storage | -20°C, dry, sealed |
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