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Paeoniflorin

Cat. No. M3941
Paeoniflorin Structure
Synonym:

NSC 178886; PF; Peoniflorin

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 45  USD45 In stock
20mg USD 35  USD35 In stock
50mg USD 65  USD65 In stock
100mg USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

Paeoniflorin could activate PI3K/Akt signaling pathway to protect the PC12 cell injury induced by Aβ25-35.Paeoniflorin most likely contributes to the therapy for liver disease by exerting anti-inflammatory effects on HHSECs through blocking IL-8 secretion via downregulation of ERK1/2 and Akt.PF alleviates psoriatic skin lesions by inhibiting inflammation, which provides new insights into the immunomodulatory effect of PF in psoriasis treatment.Paeoniflorin pretreatment protects mice against Con A-induced liver injury via inhibition of several inflammatory mediators and, at least in part, by suppressing CD4(+), CD8(+) and NKT cell infiltration in liver. The beneficial effect of paeoniflorin may be related to the downregulation of TLR4 expression and the inhibition of NF-κB activation.Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α expression partly through mTOR pathway and paeoniflorin may be a potential therapeutic agent for liver fibrosis.

Protocol (for reference only)
Cell Experiment
Cell lines PC12 cells
Preparation method Cell Viability Assessment
Cell viability was measured using a quantitative colori-metric assay with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyl tetrazolium bromide (MTT) (Sigma-Aldrich, USA) as reported previously (Mosmann 1983). Briefly, cells were seeded into collagen I-coated 96-well plates at a density of 1*104 per well. At the completion of the 24-h treatment, 10 μL MTT solution (5 mg/mL) was added. Following incubation for 4 h at 37 ℃, 100 μL dimethyl sulfoxide (DMSO) was used to dissolve crystals. The absorbance was measured using a microplate reader (Bio-Rad, USA) and cell viability was expressed as a percentage of control value.
Concentrations 0, 25, 50, 100, 200 and 400 μM
Incubation time 24 h
Animal Experiment
Animal models Adult male Sprague-Dawley rats
Formulation PBS, pH 7.5, 0.1 M at a concentration of 200 μg/μL
Dosages 15 mg/kg and 30 mg/kg for 20 consecutive days
Administration i.p.
Chemical Information
Molecular Weight 480.46
Formula C23H28O11
CAS Number 23180-57-6
Form Solid
Solubility (25°C) Water > 80 mg/mL
DMSO > 60 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gong WG, et al. Int J Biochem Cell Biol. Paeoniflorin diminishes ConA-induced IL-8 production in primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation.

[2] Sun Y, et al. Int Immunopharmacol. Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by downregulating inflammation.

[3] Chen M, et al. Int Immunopharmacol. Paeoniflorin protects against concanavalin A-induced hepatitis in mice.

[4] Zhao Y, et al. Fitoterapia. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway.

[5] Wang D, et al. Cell Mol Neurobiol. Paeoniflorin, a natural neuroprotective agent, modulates multiple anti-apoptotic and pro-apoptotic pathways in differentiated PC12 cells.

[6] Lan Z, et al. Brain Res. Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats.

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Keywords: Paeoniflorin, NSC 178886; PF; Peoniflorin supplier, HIF, inhibitors, activators


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