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HIF Hypoxia-inducible factors

Cat.No.  Name Information
M14185 Oligomycin Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.
M9066 PT2385 PT2385 is an orally active, selective inhibitor of hypoxia inducible factor (HIF)-2alpha, with a Ki value of less than 50 nM.
M5834 Oltipraz Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST).
M4869 BAY 87-2243 BAY87-2243 is a potent inhibitor of selective hypoxia-inducible facin-1 (HIF-1). Bay87-2243 induces iron death and necrosis in BRAFV600E melanoma cells by inhibiting the mitochondrial respiratory chain, resulting in ROS accumulation, lipid peroxidation, and GSH deletion.
M2558 DMOG DMOG (Dimethyloxaloylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.
M1992 2-Methoxyestradiol 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa.
M14448 Echinomycin Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM.
M14447 Acriflavine hydrochloride Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye that can be used to label nucleic acid.
M14446 Acriflavine Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.
M11130 Acetylarenobufagin Acetylarenobufagin is a steroid hypoxia inducible factor-1 (HIF-I) modulator.
M11006 IOX4 IOX4 is a selective PHD2 inhibitor,IC50 With a value of 1.6 nM, HIFα expression is induced in cells and wild-type mice to permeate the blood-brain barrier. IOX4 competes with and displaces 2-oxoglutaric acid (2OG) at the PHD2 active site.
M10990 Deoxyshikonin Deoxyshikonin was isolated from comfrey Lithospermum erythrorhizon with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNAs in HMVEC-dLy, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to HIF-specific DNA sequences.
M10501 PT2399 PT2399 is a potent and orally available antagonist of HIF-2 with an IC50 of 6 nM, PT2399 selectively disrupts the heterodimerization of HIF-2α with HIF-1β.
M10436 Belzutifan (PT2977) Belzutifan (PT2977) is a second-generation orally active and selective HIF-2α inhibitor with an IC50 of 9 nM.
M10169 Vadadustat Vadadustat is a novel, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor.
M9842 ML228 ML228 is a potent the HIF pathway activator, with EC50 values of 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively.
M9675 Desidustat Desidustat is an inhibitor of HIF hydroxylase.
M9279 LW6 LW6 is a novel HIF-1alpha inhibitor, with an IC50 of 4.4 μM.
M9198 JTZ-951 Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM.
M8979 TM6008 TM6008 is a novel PHD inhibitor, which inhibited PHD and stabilized HIF activity in vitro.

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