HIF Hypoxia-inducible factors

Cat.No.	Name	Information
M14185	Oligomycin	Oligomycin, an antifungal antibiotic, is an inhibitor of H⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.
M9066	PT2385	PT2385 is an orally active, selective inhibitor of hypoxia inducible factor (HIF)-2alpha, with a Ki value of less than 50 nM.
M5834	Oltipraz	Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST).
M4869	BAY 87-2243	BAY87-2243 is a potent inhibitor of selective hypoxia-inducible facin-1 (HIF-1). Bay87-2243 induces iron death and necrosis in BRAFV600E melanoma cells by inhibiting the mitochondrial respiratory chain, resulting in ROS accumulation, lipid peroxidation, and GSH deletion.
M2558	DMOG	DMOG (Dimethyloxaloyl glycine) is an antagonist of α-ketoglutarate cofactor and a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal. DMOG induces cell autophagy.
M1992	2-Methoxyestradiol	2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa.
M45173	3-Aminobenzoic acid	3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor.
M45009	Steppogenin	Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively.
M18039	Dencichine	Dencichine is a potent inhibitor of HIF-prolyl hydroxylase-2 (PHD-2) that induces HIF dependent HRE (hypoxia response element) in normoxic conditions.
M17121	Ethyl 3,4-dihydroxybenzoate	Ethyl 3,4-dihydroxybenzoate is a HIF-1α agonist.
M14449	HIF-2α-IN-1	HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500 nM in HIF-2α scintillation proximity assay.
M14448	Echinomycin	Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM.
M14447	Acriflavine hydrochloride	Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye that can be used to label nucleic acid.
M14446	Acriflavine	Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.
M11130	Acetylarenobufagin	Acetylarenobufagin is a steroid hypoxia inducible factor-1 (HIF-I) modulator.
M11006	IOX4	IOX4 is a selective PHD2 inhibitor,IC50 With a value of 1.6 nM, HIFα expression is induced in cells and wild-type mice to permeate the blood-brain barrier. IOX4 competes with and displaces 2-oxoglutaric acid (2OG) at the PHD2 active site.
M10990	Deoxyshikonin	Deoxyshikonin was isolated from comfrey Lithospermum erythrorhizon with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNAs in HMVEC-dLy, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to HIF-specific DNA sequences.
M10501	PT2399	PT2399 is a potent and orally available antagonist of HIF-2 with an IC50 of 6 nM, PT2399 selectively disrupts the heterodimerization of HIF-2α with HIF-1β.
M10436	Belzutifan (PT2977)	Belzutifan (PT2977) is a second-generation orally active and selective HIF-2α inhibitor with an IC50 of 9 nM.
M10169	Vadadustat	Vadadustat is a novel, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor.

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HIF Hypoxia-inducible factors

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