| Cat.No. | Name | Information |
|---|---|---|
| M1992 | 2-Methoxyestradiol | 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa. |
| M9066 | PT2385 | PT2385 is an orally active, selective inhibitor of hypoxia inducible factor (HIF)-2alpha, with a Ki value of less than 50 nM. |
| M2558 | DMOG | DMOG (Dimethyloxaloyl glycine) is an antagonist of α-ketoglutarate cofactor and a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal. DMOG induces cell autophagy. |
| M5834 | Oltipraz | Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). |
| M4869 | BAY 87-2243 | BAY87-2243 is a potent inhibitor of selective hypoxia-inducible facin-1 (HIF-1). Bay87-2243 induces iron death and necrosis in BRAFV600E melanoma cells by inhibiting the mitochondrial respiratory chain, resulting in ROS accumulation, lipid peroxidation, and GSH deletion. |
| M14185 | Oligomycin | Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. |
| M1726 | FG-4592 (Roxadustat) | FG-4592 (Roxadustat; ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor. |
| M56700 | HIF-1α-IN-3 | HIF-1α-IN-3 is a hypoxia-selective HIF-1α inhibitor. |
| M56699 | HIF-2α-IN-2 | HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor, has an IC50 of 16 nM in scintillation proximity assay (SPA). |
| M56698 | PRLX-93936 dihydrochloride | PRLX-93936 dihydrochloride is a HIF-1α inhibitor with anticancer activity. |
| M43516 | HIV-IN-7 | Axl-IN-16 is a Axl inhibitor. |
| M42441 | HIF-2α-IN-9 | HIF-2α-IN-9 is an inhibitor ofHIF-2α. |
| M42440 | PHD-IN-2 | PHD-IN-2 is a PHD antagonist (IC50: < 5 nM). |
| M42439 | PHD-IN-1 | PHD-IN-1 is a potent inhibitor of PHD2, with an IC50 value of ≤5 nM. |
| M42438 | HIF-1 inhibitor-5 | HIF-1 inhibitor-5 is a potent HIF-1 inhibitor with an IC50 of 2.38 μM. |
| M42437 | 7-Hydroxyneolamellarin A | 7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. |
| M42436 | PHD2-IN-1 | PHD2-IN-1 is a potent and orally active inhibitor of HIF prolyl hydroxylase 2 (PHD2) with an IC50 of 22.53 nM. |
| M42435 | GSK360A | GSK360A is a potent and orally active HIF-PHD inhibitor with IC50 values of 10, 100, and 126 nM for PHD1, PHD2, and PHD3, respectively. |
| M42434 | HIF-1α-IN-2 hydrochloride | HIF-1α-IN-2 hydrochloride is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). |
| M40742 | Arylsulfonamide 64B | Arylsulfonamide 64B is a HIF-1α/2α inhibitor that can be used in studies related to uveal melanoma. |
| M40741 | PT-2567 | PT-2567 is a HIF-2α inhibitor that can be used in studies related to pulmonary arterial hypertension. |
| M40740 | PMG-301 | PMG-301 is a HIF-2α inhibitor that can be used in studies related to kidney tumors. |
| M40739 | K1299 | K1299 is a HIF-2α inhibitor that can be used in studies related to renal cell carcinoma. |
| M40738 | DFF332 | DFF332 is a HIF-2α inhibitor that can be used in studies related to renal cell carcinoma. |
| M40737 | AB-521 | AB-521 is a HIF-2α inhibitor that can be used in studies related to hepatocellular carcinoma and renal cell carcinoma. |
| M40736 | NKT2152 | NKT2152 is a small molecule inhibitor of HIF-2α that can be used in studies related to renal cell carcinoma. |
| M31057 | TAT-cyclo-CLLFVY TFA | TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY TFA disrupts HIF-1α/HIF-1β protein-protein interaction with an IC50 of 1.3 μM. |
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