| Cat.No. | Name | Information |
|---|---|---|
| M1992 | 2-Methoxyestradiol | 2-methoxyestradiol (2-ME2), an endogenous metabolite of 17β -estradiol (E2) with oral activity, is an apoptosis inducer and angiogenesis inhibitor with effective antitumor activity. Methoxyestradiol can also destabilize microtubules. Methoxyestradiol is a potent inhibitor of superoxide dismutase (SOD) and reactive oxygen species (ROS) that can induce autophagy in transformed cell line HEK293, cancer cell line U87 and HeLa. |
| M9066 | PT2385 | PT2385 is an orally active, selective inhibitor of hypoxia inducible factor (HIF)-2alpha, with a Ki value of less than 50 nM. |
| M2558 | DMOG | DMOG (Dimethyloxaloylglycine) is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase. |
| M5834 | Oltipraz | Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). |
| M4869 | BAY 87-2243 | BAY87-2243 is a potent inhibitor of selective hypoxia-inducible facin-1 (HIF-1). Bay87-2243 induces iron death and necrosis in BRAFV600E melanoma cells by inhibiting the mitochondrial respiratory chain, resulting in ROS accumulation, lipid peroxidation, and GSH deletion. |
| M14185 | Oligomycin | Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. |
| M9675 | Desidustat | Desidustat is an inhibitor of HIF hydroxylase. |
| M9279 | LW6 | LW6 is a novel HIF-1alpha inhibitor, with an IC50 of 4.4 μM. |
| M9198 | JTZ-951 | Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. |
| M8979 | TM6008 | TM6008 is a novel PHD inhibitor, which inhibited PHD and stabilized HIF activity in vitro. |
| M8963 | JNJ-42041935 | JNJ-42041935 is a potent, competitive, reversible, and selective inhibitor of PHD with pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09 for PHD1, PHD2, and PHD3, respectively. |
| M8924 | Daprodustat | Daprodustat (GSK1278863) is a novel, first-in-class, orally active inhibitor of hypoxia-induced factor prolyl hydroxylase (HIF-PHI). Reversible inhibition of HIF-PHD activity under normal partial oxygen pressure can temporarily inhibit HIF-α degradation and promote the expression of related hypoxia metabolism genes. |
| M8424 | KC7F2 | KC7F2 is a cell permeable potent hypoxia inducible factor-1 (HIF-1) pathway inhibitor, with IC50 of 20 μM in LN229-HRE-AP cells, and with potential as a cancer therapy agent. |
| M7929 | PX 12 | Px-12 (IV-2) is a reversible thioredoxin 1 (TRX-1) inhibitor. |
| M5795 | Molidustat (BAY 85-3934) | Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. |
| M5276 | MK-8617 | MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively. |
| M5146 | PX-478 2HCl | PX-478 2HCl is an orally active selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 crosses the blood-brain barrier. |
| M4102 | Notoginsenoside-Ft1 | Notoginsenoside Ft1(Notoginsenoside Ft1) is a plant isolated panax Notoginsenoside that stimulates angiogenesis. |
| M3991 | Lificiguat | Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. |
| M3977 | Chlorogenic acid | Chlorogenic Acid is an analog of caffeic acid that displays antioxidant, analgesic, antipyretic and chemopreventive activity. |
| M3941 | Paeoniflorin | Paeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. Paeoniflorin has been used as an anticonvulsant and has hypoglycemic effect. |
| M3231 | Hydralazine hydrochloride | Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. |
| M2573 | IOX2 | IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH. |
| M1726 | FG-4592 (Roxadustat) | FG-4592 (Roxadustat; ASP1517) is a novel Hypoxia Inducible Factor Prolyl Hydroxylase inhibitor. |
| M43516 | HIV-IN-7 | Axl-IN-16 is a Axl inhibitor. |
| M42441 | HIF-2α-IN-9 | HIF-2α-IN-9 is an inhibitor ofHIF-2α. |
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