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Acriflavine

Cat. No. M14446
Acriflavine Structure
Synonym:

Acriflavinium chloride 3,6-Acridinediamine mix

Size Price Availability Quantity
100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.

Chemical Information
Molecular Weight 259.73
CAS Number 8048-52-0
Solubility (25°C) Water ≥ 25 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Somayeh Vandghanooni, et al. Acriflavine-loaded solid lipid nanoparticles: preparation, physicochemical characterization, and anti-proliferative properties

[2] Rawan Nehme, et al. Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment

[3] Rawan Hallal, et al. Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells

[4] Govindaraj Usha, et al. Supramolecular Assembly of Acriflavine on Graphene Oxide for the Sensing of Adenosine Phosphates

[5] Danica Sabolova, et al. Proflavine/acriflavine derivatives with versatile biological activities

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