Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.
| Molecular Weight | 259.73 |
| CAS Number | 8048-52-0 |
| Solubility (25°C) | Water ≥ 25 mg/mL |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Rawan Nehme, et al. Repurposing of Acriflavine to Target Chronic Myeloid Leukemia Treatment
[3] Rawan Hallal, et al. Acriflavine targets oncogenic STAT5 signaling in myeloid leukemia cells
[5] Danica Sabolova, et al. Proflavine/acriflavine derivatives with versatile biological activities
| Related HIF Products |
|---|
| Steppogenin
Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. |
| HIV-IN-7
Axl-IN-16 is a Axl inhibitor. |
| HIF-2α-IN-9
HIF-2α-IN-9 is an inhibitor ofHIF-2α. |
| PHD-IN-2
PHD-IN-2 is a PHD antagonist (IC50: < 5 nM). |
| PHD-IN-1
PHD-IN-1 is a potent inhibitor of PHD2, with an IC50 value of ≤5 nM. |
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