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Deoxyshikonin was isolated from comfrey Lithospermum erythrorhizon with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNAs in HMVEC-dLy, promotes the interaction of HIF-1α and HIF-1β subunits, and binds to HIF-specific DNA sequences.
| Molecular Weight | 272.3 |
| Formula | C16H16O4 |
| CAS Number | 43043-74-9 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[4] Ju-Hyun Kim, et al. Biopharm Drug Dispos. Deoxyshikonin reversibly inhibits cytochrome P450 2B6
| Related HIF Products |
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| PRLX-93936 dihydrochloride
PRLX-93936 dihydrochloride is a HIF-1α inhibitor with anticancer activity. |
| 3-Aminobenzoic acid
3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor. |
| Steppogenin
Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. |
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