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KC7F2 is a cell permeable potent hypoxia inducible factor-1 (HIF-1) pathway inhibitor, with IC50 of 20 μM in LN229-HRE-AP cells, and with potential as a cancer therapy agent. KC7F2 inhibits the activation of HIF-target genes such as carbonic anhydrase IX, matrix metalloproteinase 2 (MMP2), enolase 1, and endothelin 1. KC7F2 suppresses the protein accumulation of HIF-1 in cancer cell lines by inhibition of its protein synthesis at the translation level. KC7F2 is preferentially cytotoxicity to cancer cells, an effect that is increased in hypoxia.
| Molecular Weight | 570.38 |
| Formula | C16H16Cl4N2O4S4 |
| CAS Number | 927822-86-4 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HIF Products |
|---|
| HIF-1α-IN-3
HIF-1α-IN-3 is a hypoxia-selective HIF-1α inhibitor. |
| HIF-2α-IN-2
HIF-2α-IN-2 is a hypoxia-inducible factors (HIF-2α) inhibitor, has an IC50 of 16 nM in scintillation proximity assay (SPA). |
| PRLX-93936 dihydrochloride
PRLX-93936 dihydrochloride is a HIF-1α inhibitor with anticancer activity. |
| 3-Aminobenzoic acid
3-Aminobenzoic acid is a hypoxia-inducible factor-1α (HIF-1α) inhibitor. |
| Steppogenin
Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. |
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