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PX-478 2HCl

Cat. No. M5146

All AbMole products are for research use only, cannot be used for human consumption.

PX-478 2HCl Structure
Synonym:

PX-478 dihydrochloride

Size Price Availability Quantity
5mg USD 81  USD81 In stock
10mg USD 147  USD147 In stock
50mg USD 352  USD352 In stock
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Biological Activity

PX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells. PX-478 causes reduced fibrosis and fewer inflammatory infiltrates in high-fat-diet mice adipose tissues.

Customer Product Validations & Biological Datas
Source Oncotarget (2017). Figure 1. PX-478
Method Western blot
Cell Lines MiaPaCa2 cells
Concentrations 10, 20, 50, 100, and 200 μM
Incubation Time 6h
Results When MiaPaCa2 cells were exposed to the highest concentration of PX-478 and noscapine, HIF-1 expression levels equaled to 55% and 62% of the control value, respectively.
Chemical Information
Molecular Weight 394.12
Formula C13H20Cl4N2O3
CAS Number 685898-44-6
Solubility (25°C) DMSO 60 mg/mL
Water 35 mg/mL
Storage -20°C, dry, sealed
References

[1] Sun K, et al. Mol Cell Biol. Selective inhibition of hypoxia-inducible factor 1α ameliorates adipose tissue dysfunction.

[2] Palayoor ST, et al. Int J Cancer. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells.

[3] Koh MY, et al. Mol Cancer Ther. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha.

[4] Welsh S, et al. Mol Cancer Ther. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

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  Catalog
Abmole Inhibitor Catalog




Keywords: PX-478 2HCl, PX-478 dihydrochloride supplier, HIF, inhibitors, activators

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