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Oltipraz

Cat. No. M5834
Oltipraz Structure
Synonym:

RP 35972; NSC 347901

Size Price Availability Quantity
5mg USD 35  USD35 In stock
10mg USD 55  USD55 In stock
50mg USD 105  USD105 In stock
100mg USD 155  USD155 In stock
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Quality Control & Documentation
Biological Activity

Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST). 

Product Citations
Chemical Information
Molecular Weight 226.34
Formula C8H6N2S3
CAS Number 64224-21-1
Solubility (25°C) 36 mg/mL warmed in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Noorafshan A, et al. Bull Emerg Trauma. The Effects of Oltipraz on Tissue Regeneration in the Process of Wound Healing: A Stereological Study.

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Keywords: Oltipraz, RP 35972; NSC 347901 supplier, HIF, inhibitors, activators


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