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Chlorogenic acid inhibited the proliferation of A549 human cancer cells in vitro.Chlorogenic acid suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced neoplastic transformation of JB6 P+ cells in a dose-dependent manner.Chlorogenic acid also increased the enzymatic activities of glutathione S-transferases (GST) and NAD(P)H: quinone oxidoreductase. Further studies indicated that chlorogenic acid could stimulate the nuclear translocation of Nrf2 (NF-E2-related factor) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST activity.Chlorogenic acid inhibits Bcr-Abl (the fusion protein of Bcr and c-Abl) tyrosine kinase and triggers MAP kinases p38-dependent apoptosis.
| Molecular Weight | 354.31 |
| Formula | C16H18O9 |
| CAS Number | 327-97-9 |
| Solubility (25°C) | DMSO 32 mg/mL |
| Storage | 2-8°C, dry, sealed |
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