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Acriflavine hydrochloride

Cat. No. M14447
Acriflavine hydrochloride Structure
Synonym:

Acriflavinium chloride hydrochloride

Size Price Availability Quantity
500mg USD 48  USD48 In stock
1g USD 60  USD60 In stock
5g USD 125  USD125 In stock
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Quality Control & Documentation
Biological Activity

Acriflavine hydrochloride (Acriflavinium chloride hydrochloride) is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic. Acriflavine hydrochloride is a potent HIF-1 inhibitor, with antitumor activity. Acriflavine hydrochloride has antimicrobial and antiviral activities. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2

Chemical Information
Molecular Weight 541.9
CAS Number 69235-50-3
Solubility (25°C) DMSO 25 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ankita Tehlan, et al. Antibacterial action of acriflavine hydrochloride for eradication of the gastric pathogen Helicobacter pylori

[2] C Manivannan, et al. Investigation on the inclusion and toxicity of acriflavine with cyclodextrins: a spectroscopic approach

[3] Florian S Fuchs, et al. Confocal laser endomicroscopy for diagnosing lung cancer in vivo

[4] Dan Ionut Gheonea, et al. Confocal laser endomicroscopy of the colon

[5] D K McLoughlin, et al. Effect of quinacrine hydrochloride and acriflavine hydrochloride on development and stability of resistance to dimetridazole by Tritrichomonas foetus

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  Catalog
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Keywords: Acriflavine hydrochloride, Acriflavinium chloride hydrochloride supplier, HIF, inhibitors, activators


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