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Echinomycin

Cat. No. M14448
Echinomycin Structure
Synonym:

Quinomycin A; NSC-13502

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1mg USD 350  USD350 1-2 Weeks
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Quality Control & Documentation
Biological Activity

Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM.

Chemical Information
Molecular Weight 1101.26
CAS Number 512-64-1
Solubility (25°C) DMSO 5.3 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Walhan Alshaer, et al. Encapsulation of echinomycin in cyclodextrin inclusion complexes into liposomes: in vitro anti-proliferative and anti-invasive activity in glioblastoma

[2] Flavia Plastino, et al. Echinomycin mitigates ocular angiogenesis by transcriptional inhibition of the hypoxia-inducible factor-1

[3] Keita Kojima, et al. Total Synthesis of Echinomycin and Its Analogues

[4] Michio Sato, et al. Echinomycin biosynthesis

[5] M J Waring. Echinomycin

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  Catalog
Abmole Inhibitor Catalog




Keywords: Echinomycin, Quinomycin A; NSC-13502 supplier, HIF, inhibitors, activators


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