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1,4-DPCA, a potent prolyl-4-hydroxylase inhibitor, is a collagen hydroxylation inhibitor in human foreskin fibroblasts with an IC50 of 2.4 µM. 1,4-DPCA inhibits prolyl-4-hydroxylases α isoforms stabilizes HIF-1α protein. 1,4-DPCA also inhibits factor inhibiting HIF (FIH) with an IC50 of 60 μM.
| Molecular Weight | 240.21 |
| Formula | C13H8N2O3 |
| CAS Number | 331830-20-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 12.5 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Yong Zhang, et al. Sci Transl Med. Drug-induced regeneration in adult mice
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