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Nimodipine (Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.
Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system.
Nimodipine (0.2 µg/µl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration. Nimodipine (0.1~80 mg/kg; p.o.) results in a significant dose-dependent inhibition of spontaneous metastasis.
| Molecular Weight | 418.44 |
| Formula | C21H26N2O7 |
| CAS Number | 66085-59-4 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage | -20°C, protect from light, sealed |
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