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Glycodeoxycholic Acid

Cat. No. M11303
Glycodeoxycholic Acid Structure
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100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Glycodeoxycholic Acid is an endogenous metabolite.

Chemical Information
Molecular Weight 449.63
Formula C26H43NO5
CAS Number 360-65-6
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alessandro Mantovani, et al. Metabolites. Plasma Bile Acid Profile in Patients with and without Type 2 Diabetes

[2] Bo Zhu, et al. J Zhejiang Univ Sci B. Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus

[3] Pierluigi Giampaolino, et al. Int J Mol Sci. Microbiome and PCOS: State-of-Art and Future Aspects

[4] Benjamin L Woolbright, et al. Toxicol Sci. Glycodeoxycholic acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients

[5] G Xu, et al. Gastroenterology. Glycocholic acid and glycodeoxycholic acid but not glycoursocholic acid inhibit bile acid synthesis in the rabbit

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