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Desthiazolylmethyloxycarbonyl Ritonavir

Cat. No. M1573
Desthiazolylmethyloxycarbonyl Ritonavir Structure
Synonym:

Desthiazolylmethyloxycarbonyl Ritonavir

Size Price Availability
5mg USD 150  USD150 Custom Synthesis
50mg USD 1200  USD1200 Custom Synthesis
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Quality Control & Documentation
Biological Activity

Desthiazolylmethyloxycarbonyl Ritonavir is a metabolite of Ritonavir, which is a HIV protease inhibitor.

Chemical Information
Molecular Weight 579.8
Formula C32H45N5O3S
CAS Number 176655-55-3
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Francisca Verdugo-Paiva, et al. Lopinavir-ritonavir for COVID-19: A living systematic review

[2] Xi Liu, et al. Efficacy of chloroquine versus lopinavir/ritonavir in mild/general COVID-19 infection: a prospective, open-label, multicenter, randomized controlled clinical study

[3] Thai Nguyen, et al. Drug Interactions with Cobicistat- or Ritonavir-Boosted Elvitegravir

[4] Jamie D Croxtall, et al. Lopinavir/Ritonavir: a review of its use in the management of HIV-1 infection

[5] D J Porche. Lopinavir/ritonavir

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Keywords: Desthiazolylmethyloxycarbonyl Ritonavir, Desthiazolylmethyloxycarbonyl Ritonavir supplier, Metabolite/Endogenous Metabolite, inhibitors, activators


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