Free shipping on all orders over $ 500

Stavudine

Cat. No. M2137
Stavudine Structure
Synonym:

d4T

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 35  USD35 In stock
100mg USD 60  USD60 In stock
200mg USD 85  USD85 In stock
500mg USD 120  USD120 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Stavudine (d4T, brand name Zerit) is an orally bioavailable nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV. Stavudine triphosphate inhibits the HIV reverse transcriptase in vitro by competing with natural substrate, thymidine triphosphate. Stavudine also causes termination of DNA replication by incorporating into the DNA strand. In clinical studies, stavudine has excellent oral bioavailability in excess of 80%.

Chemical Information
Molecular Weight 224.21
Formula C10H12N2O4
CAS Number 3056-17-5
Solubility (25°C) DMSO 40 mg/mL
Water 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wangsomboonsiri W, et al. Clin Infect Dis. Association between HLA-B*4001 and lipodystrophy among HIV-infected patients from Thailand who received a stavudine-containing antiretroviral regimen.

[2] Riddler SA, et al. Antiviral Res. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T).

Related Reverse Transcriptase Products
Rovafovir etalafenamide

Rovafovir etalafenamide (GS-9131), a proagent of the adenosine nucleotide analogue GS-9148, is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Rovafovir etalafenamide is potent and active against a variety of NRTI mutants, and shows potent anti-HIV-1 activity.

Azvudine hydrochloride

Azvudine (RO-0622) hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine hydrochloride exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine hydrochloride inhibits NRTI-resistant viral strains.

Azvudine

Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains.

Ulonivirine

Ulonivirine (MK-8507) is an orally active non-nucleoside reverse transcriptase inhibitor with high antiviral activity.Ulonivirine is used in the study of HIV-1 infection.

Tenofovir alafenamide fumarate

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

  Catalog
Abmole Inhibitor Catalog




Keywords: Stavudine, d4T supplier, Reverse Transcriptase, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.