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Zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NARTI).Zalcitabine is an analog of pyrimidine. It is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3’ with a hydrogen.It is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite works as a substrate for HIV reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. Since zalcitabine is a reverse transcriptase inhibitor it possess activity only against retroviruses.
| Molecular Weight | 211.22 |
| Formula | C9H13N3O3 |
| CAS Number | 7481-89-2 |
| Solubility (25°C) | DMSO 40 mg/mL Water ≥ 35 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] M J Shelton, et al. Zalcitabine
[4] J J Lipsky. Zalcitabine and didanosine
[5] D Devineni, et al. Zalcitabine. Clinical pharmacokinetics and efficacy
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