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Zalcitabine

Cat. No. M3347
Zalcitabine Structure
Synonym:

ddC; Dideoxycytidine; 2',3'-Dideoxycytidine

Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NARTI).Zalcitabine is an analog of pyrimidine. It is a derivative of the naturally existing deoxycytidine, made by replacing the hydroxyl group in position 3’ with a hydrogen.It is phosphorylated in T cells and other HIV target cells into its active triphosphate form, ddCTP. This active metabolite works as a substrate for HIV reverse transcriptase, and also by incorporation into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group. Since zalcitabine is a reverse transcriptase inhibitor it possess activity only against retroviruses.

Chemical Information
Molecular Weight 211.22
Formula C9H13N3O3
CAS Number 7481-89-2
Solubility (25°C) DMSO 40 mg/mL
Water ≥ 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Antn L Martnez, et al. Identification of Novel Regulators of Zalcitabine-Induced Neuropathic Pain

[2] J C Adkins, et al. Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection

[3] M J Shelton, et al. Zalcitabine

[4] J J Lipsky. Zalcitabine and didanosine

[5] D Devineni, et al. Zalcitabine. Clinical pharmacokinetics and efficacy

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Keywords: Zalcitabine, ddC; Dideoxycytidine; 2',3'-Dideoxycytidine supplier, Reverse Transcriptase, inhibitors, activators


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