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Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. Doravirine is highly specific with minimum off-target activities.
| Molecular Weight | 425.75 |
| Formula | C17H11C1F3N5O3 |
| CAS Number | 1338225-97-0 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Alexander J Stockdale, et al. Curr Opin HIV AIDS. Doravirine: its role in HIV treatment
[3] No authors listed. Doravirine
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