Free shipping on all orders over $ 500

Doravirine

Cat. No. M20577

All AbMole products are for research use only, cannot be used for human consumption.

Doravirine Structure
Synonym:

MK1439

Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 235  USD235 In stock
25mg USD 450  USD450 In stock
50mg USD 690  USD690 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. Doravirine is highly specific with minimum off-target activities.

Chemical Information
Molecular Weight 425.75
Formula C17H11C1F3N5O3
CAS Number 1338225-97-0
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Guangdi Li, et al. Acta Pharm Sin B. Approved HIV reverse transcriptase inhibitors in the past decade

[2] Alexander J Stockdale, et al. Curr Opin HIV AIDS. Doravirine: its role in HIV treatment

[3] No authors listed. Doravirine

[4] No authors listed. Doravirine

[5] Matt S Anderson, et al. Clin Pharmacokinet. A Two-Way Steady-State Pharmacokinetic Interaction Study of Doravirine (MK-1439) and Dolutegravir

Related Reverse Transcriptase Products
Fosalvudine tidoxil

Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI).

Emtricitabine triphosphate tetrasodium salt

Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of Emtricitabine triphosphate and a nucleoside reverse transcriptase inhibitor (NRTI) targeting HIV and HBV.

M-MLV Reverse transcriptase

M-MLV Reverse transcriptase (M-MLV RT) is a kind of Reverse transcriptase, from the moroni mouse leukemia virus (MoMLV).

ddUTP

ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) is a selective HIV and AMV reverse transcriptase inhibitor with Ki values of 0.05 µM and 1 µM, respectively.

Rovafovir etalafenamide

Rovafovir etalafenamide (GS-9131), a proagent of the adenosine nucleotide analogue GS-9148, is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Rovafovir etalafenamide is potent and active against a variety of NRTI mutants, and shows potent anti-HIV-1 activity.

  Catalog
Abmole Inhibitor Catalog




Keywords: Doravirine, MK1439 supplier, Reverse Transcriptase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.