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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M21356 | Ulonivirine | Ulonivirine (MK-8507) is an orally active non-nucleoside reverse transcriptase inhibitor with high antiviral activity.Ulonivirine is used in the study of HIV-1 infection. |
| M20784 | Tenofovir alafenamide fumarate | Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
| M20783 | Tenofovir alafenamide hemifumarate | Tenofovir alafenamide (TAF, GS-7340) hemifumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection. |
| M20702 | Alovudine | 3'-Fluoro-3'-deoxythymidine (Alovudine) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer. |
| M20577 | Doravirine (MK-1439) | Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. |
| M20483 | 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride | 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor. |
| M20468 | Entecavir | Entecavir, a new deoxyguanine nucleoside analogue, is a selective inhibitor of the replication of the hepatitis B virus (HBV). |
| M5605 | Efavirenz | Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture. |
| M5050 | Adefovir Dipivoxil | Adefovir Dipivoxil is a reverse transcriptase inhibitor, used in the treatment of chronic hepatitis B virus (HBV). |
| M3381 | Nevirapine | Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. |
| M3355 | Didanosine | Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. |
| M3352 | Lamivudine (BCH-189) | Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) with an IC50 of 2.7 mM. Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS. |
| M3347 | Zalcitabine | Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI). |
| M3342 | Emtricitabine | Emtricitabine is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM. |
| M3205 | Zidovudine | Zidovudine is a reverse transcriptase inhibitor. |
| M2980 | Rilpivirine (R278474) | Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). |
| M2694 | Etravirine | Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. |
| M2575 | Dapivirine | Dapivirine is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. |
| M2363 | Abacavir sulfate | Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1. |
| M2137 | Stavudine | Stavudine (D4T) is a potent inhibitor of HIV-1 reverse transcriptase in vitro. |
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