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Reverse Transcriptase Reverse Transcriptase

Cat.No.  Name Information
M27630 Azvudine Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains.
M20784 Tenofovir alafenamide fumarate Tenofovir alafenamide (TAF, GS-7340) fumarate is a precursor compound of Tenofovir and a novel nucleotide reverse transcriptase inhibitor for use in studies related to HIV-1 infection.
M20577 Doravirine Doravirine (MK-1439) is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay.
M10188 2,2'-Cyclouridine 2,2'-Cyclouridine is a research tool for antiviral and anticancer studies.
M5605 Efavirenz Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
M5051 Tenofovir Tenofovir is a nucleotide reverse transcriptase inhibitor used in studies related to HIV and chronic hepatitis B (HBV).
M5050 Adefovir Dipivoxil Adefovir dipivoxil, an adenosine analogue, is an oral proagent of the nucleoside reverse transcriptase inhibitor Adefovir.
M3381 Nevirapine Nevirapine (NSC 641530) is a potent, specific non-nucleoside reverse transcriptase inhibitor (NNRTIs) that non-competitively inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with a Ki of 220 nM. Nevirapine (NSC 641530) can be used in AIDS-related researchs.
M3355 Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
M3352 Lamivudine (BCH-189) Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) with an IC50 of 2.7 mM. Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS.
M3347 Zalcitabine Zalcitabine is a nucleoside analog HIV reverse transcriptase inhibitor (NARTI).
M3342 Emtricitabine Emtricitabine is a nucleoside reverse transcriptase inhibitor with an IC50 of 27.7 μM.
M3205 Zidovudine Zidovudine is a reverse transcriptase inhibitor.
M2980 Rilpivirine (R278474) Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM).
M2694 Etravirine Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
M2575 Dapivirine Dapivirine is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM.
M2363 Abacavir sulfate Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
M2137 Stavudine Stavudine (D4T) is a potent inhibitor of HIV-1 reverse transcriptase in vitro. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis.
M41244 Fosalvudine tidoxil Fosalvudine tidoxil is an orally active nucleoside reverse transcriptase inhibitor (NRTI).
M41243 Emtricitabine triphosphate tetrasodium salt Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of Emtricitabine triphosphate and a nucleoside reverse transcriptase inhibitor (NRTI) targeting HIV and HBV.

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