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Nevirapine

Cat. No. M3381
Nevirapine Structure
Synonym:

BI-RG 587; NSC 641530; NVP

Size Price Availability Quantity
10mg USD 45  USD45 In stock
50mg USD 70  USD70 In stock
100mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Nevirapine (NSC 641530) is a potent, specific non-nucleoside reverse transcriptase inhibitor (NNRTIs) that non-competitively inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with a Ki of 220 nM. Nevirapine (NSC 641530) can be used in AIDS-related researchs.

Chemical Information
Molecular Weight 266.3
Formula C15H14N4O
CAS Number 129618-40-2
Solubility (25°C) DMSO 15 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aline T Marinho, et al. Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity

[2] J-J Parienti, et al. Nevirapine and cardiovascular risk

[3] M Popovic, et al. Nevirapine hypersensitivity

[4] Ana Milinkovic, et al. Nevirapine in the treatment of HIV

[5] M Mirochnick, et al. Nevirapine: pharmacokinetic considerations in children and pregnant women

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Keywords: Nevirapine, BI-RG 587; NSC 641530; NVP supplier, Reverse Transcriptase, inhibitors, activators


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