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Tenofovir

Cat. No. M5051
Tenofovir Structure
Synonym:

GS 1278; PMPA; TDF

Size Price Availability Quantity
5mg USD 40  USD40 In stock
10mg USD 50  USD50 In stock
50mg USD 95  USD95 In stock
100mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Tenofovir is a nucleotide reverse transcriptase inhibitor used in studies related to HIV and chronic hepatitis B (HBV).

Chemical Information
Molecular Weight 287.21
Formula C9H14N5O4P
CAS Number 147127-20-6
Form Solid
Solubility (25°C) DMSO 4 mg/mL warmed
Water 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Miller MD,et.al. Nucleosides Nucleotides Nucleic Acids. Antiviral activity of tenofovir (PMPA) against nucleoside-resistant clinical HIV samples.

[2] Ying C,et.al. J Viral Hepat. Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir.

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Keywords: Tenofovir, GS 1278; PMPA; TDF supplier, Reverse Transcriptase, inhibitors, activators


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