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Lamivudine (BCH-189) is a potent nucleoside analog reverse transcriptase inhibitor with an IC50 of 2.7 mM. The pH-driven uptake of TEA by BBMV (pHin = 6.0, pHout = 7.5) was inhibited by lamivudine. The IC50 value (concentration resulting in 50% inhibition) for the concentration-dependent effect of lamivudine on TEA uptake by BBMV after 30 s was 2668 uM whereas IC50 values for cimetidine and trimethoprim were < 2.5 uM and < 25 uM, respectively. The early uptake of TEA by BLMV was also reduced significantly by lamivudine. The IC50 value for the concentration-dependent effect of lamivudine on uptake of TEA by BLMV at 30 s was > 25 mM, whereas the IC50 values for cimetidine and trimethoprim were 2116 uM and 445uM, respectively.
| Molecular Weight | 229.26 |
| Formula | C8H11N3O3S |
| CAS Number | 134678-17-4 |
| Solubility (25°C) | Water 50 mg/mL DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Lesley J Scott. Dolutegravir/Lamivudine Single-Tablet Regimen: A Review in HIV-1 Infection
[3] Princy N Kumar, et al. Lamivudine for the treatment of HIV
[4] Tim Ibbotson, et al. Lamivudine/zidovudine/abacavir: triple combination tablet
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