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Didanosine

Cat. No. M3355
Didanosine Structure
Synonym:

2',3'-Dideoxyinosine; ddI

Size Price Availability Quantity
10mg USD 70  USD70 In stock
50mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Didanosine (Videx, Videx EC) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. It is effective against HIV and used in combination with other antiretroviral compound therapy as part of highly active antiretroviral therapy (HAART).

Chemical Information
Molecular Weight 236.23
Formula C10H12N4O3
CAS Number 69655-05-6
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Santiago Moreno, et al. Didanosine enteric-coated capsule: current role in patients with HIV-1 infection

[2] David A Cooper. Update on didanosine

[3] R B Pollard. Didanosine once daily: potential for expanded use

[4] J J Lipsky. Zalcitabine and didanosine

[5] M J Shelton, et al. Didanosine

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Keywords: Didanosine, 2',3'-Dideoxyinosine; ddI supplier, Reverse Transcriptase, inhibitors, activators


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