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Etravirine

Cat. No. M2694
Etravirine  Structure
Synonym:

R-165335

Size Price Availability Quantity
5mg USD 65  USD65 In stock
10mg USD 100  USD100 In stock
25mg USD 170  USD170 In stock
50mg USD 270  USD270 In stock
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Quality Control & Documentation
Biological Activity

Etravirine (TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Chemical Information
Molecular Weight 435.28
Formula C20H15BrN6O
CAS Number 269055-15-4
Solubility (25°C) DMSO 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Joshua P Havens, et al. Clinical Pharmacokinetics and Pharmacodynamics of Etravirine: An Updated Review

[2] No authors listed. Etravirine

[3] No authors listed. Etravirine

[4] Emma D Deeks, et al. Etravirine

[5] Bettina M Knoll, et al. Etravirine

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