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Adefovir Dipivoxil

Cat. No. M5050
Adefovir Dipivoxil Structure
Synonym:

GS 0840

Size Price Availability Quantity
10mM*1mL in DMSO USD 54  USD54 In stock
50mg USD 49  USD49 In stock
100mg USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Adefovir Dipivoxil reduces Liver HBV DNA to <0.1 pg of viral DNA per mg of total DNA (pg/mg) in transgenic mice expressing hepatitis B virus. Adefovir Dipivoxil treatment also reduces serum HBV DNA to 3.5 log10 genomic equivalents (ge)/mL in transgenic mice expressing hepatitis B virus compared to 5.3 log10 ge/mL for the placebo control group. Adefovir Dipivoxil antiviral activity reaches near maximum viral reduction by day 10 in the liver and reaches an endpoint of liver virus inhibition at 1.0 mg/kg/day. Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

Chemical Information
Molecular Weight 501.47
Formula C20H32N5O8P
CAS Number 142340-99-6
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Manolakopoulos S,et.al. Aliment Pharmacol Ther. Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine.

[2] Marcellin P,et.al. N Engl J Med. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.

[3] Julander JG,et.al. Antiviral Res. Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virus.

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Keywords: Adefovir Dipivoxil, GS 0840 supplier, Reverse Transcriptase, inhibitors, activators


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