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Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy.
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
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| Animal models | Rats |
| Formulation | |
| Dosages | 0-1 mg/day |
| Administration | i.p. |
| Molecular Weight | 416.57 |
| Formula | C24H32O4S |
| CAS Number | 52-01-7 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Laura Carone, et al. Spironolactone
| Related Mineralocorticoid Receptor Products |
|---|
| 18-Oxocortisol
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). |
| Lorundrostat
Lorundrostat is an aldosterone synthase inhibitor and is used in studies related to hypertension. |
| LY2623091
LY2623091 is a salicorticoid receptor (MR) antagonist that may be used in studies related to chronic kidney disease and hypertension. |
| Desoxycorticosterone pivalate
Desoxycorticosterone pivalate (DOCP) is a salt corticosteroid that may be used in studies related to primary hypoadrenocorticism (PH). |
| Ocedurenone
Ocedurenone is a novel nonsteroidal salicorticoid receptor (MR) antagonist that may be used in studies related to kidney disease. |
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