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Osilodrostat (LCI699) is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively.
In HAC15 cells, osilodrostat inhibited cortisol production more potently (IC50 = 0.035 µM).
| Molecular Weight | 227.24 |
| Formula | C13H10FN3 |
| CAS Number | 928134-65-0 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL Ethanol 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Mineralocorticoid Receptor Products |
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