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Balcinrenone (AZD9977) is a potent, selective, and orally active modulator of corticosteroid receptors (MR). AZD9977 was studied for heart failure and chronic kidney disease.
Balcinrenone (AZD9977) (oral administration; 10-100 mg/kg; 4 weeks) dose dependently reduces the UACR compared to vehicle in uni-nephrectomised male Sprague Dawley rats administered aldosterone and fed a high-salt diet. Balcinrenone is as efficacious as full MR antagonists on renal protection, despite the partial antagonism observed in in vitro assays.
| Molecular Weight | 399.37 |
| Formula | C20H18FN3O5 |
| CAS Number | 1850385-64-6 |
| Solubility (25°C) | DMSO ≥ 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Mineralocorticoid Receptor Products |
|---|
| 18-Oxocortisol
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). |
| Lorundrostat
Lorundrostat is an aldosterone synthase inhibitor and is used in studies related to hypertension. |
| LY2623091
LY2623091 is a salicorticoid receptor (MR) antagonist that may be used in studies related to chronic kidney disease and hypertension. |
| Desoxycorticosterone pivalate
Desoxycorticosterone pivalate (DOCP) is a salt corticosteroid that may be used in studies related to primary hypoadrenocorticism (PH). |
| Ocedurenone
Ocedurenone is a novel nonsteroidal salicorticoid receptor (MR) antagonist that may be used in studies related to kidney disease. |
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