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AZD9977

Cat. No. M11399
AZD9977  Structure
Size Price Availability Quantity
5mg USD 350  USD350 In stock
10mg USD 520  USD520 In stock
25mg USD 925  USD925 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AZD9977 is a potent, selective, and orally active modulator of corticosteroid receptors (MR). AZD9977 was studied for heart failure and chronic kidney disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 399.37
Formula C20H18FN3O5
CAS Number 1850385-64-6
Purity >99%
Solubility DMSO ≥ 200 mg/mL
Storage at -20°C
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Keywords: AZD9977 supplier, Mineralocorticoid Receptor, inhibitors

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