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Potassium canrenoate

Cat. No. M3173
Potassium canrenoate Structure
Synonym:

Aldadiene potassium, SC-14266

Size Price Availability Quantity
100mg USD 40  USD40 In stock
500mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Canrenoate potassium is a predrug for the release of Canrenone and an effective antagonist of competitive salt ocorticoid receptor. As a diuretic, Canrenoate potassium is used in the study of hypertension.

Chemical Information
Molecular Weight 396.56
Formula C22H29KO4
CAS Number 2181-04-6
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Katarzyna Kotfis, et al. COVID-19-The Potential Beneficial Therapeutic Effects of Spironolactone during SARS-CoV-2 Infection

[2] Clothilde Berger, et al. Patients with acute heart failure treated with the CARRESS-HF diuretic protocol in association with canrenoate potassium: Tolerance of high doses of canrenoate potassium

[3] Serena Logrippo, et al. Potassium canrenoate compounding for administration via enteral feeding tubes: a physical and microbiological stability study

[4] Maysa Suyagh, et al. Potassium canrenoate treatment in paediatric patients: a population pharmacokinetic study using novel dried blood spot sampling

[5] Romain Bos, et al. Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat

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Keywords: Potassium canrenoate, Aldadiene potassium, SC-14266 supplier, Mineralocorticoid Receptor, inhibitors, activators


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