Free shipping on all orders over $ 500

Dexamethasone Sodium Phosphate

Cat. No. M2626
Dexamethasone Sodium Phosphate Structure
Synonym:

Dexamethasone phosphate disodium

Size Price Availability Quantity
50mg USD 30  USD30 In stock
100mg USD 45  USD45 In stock
500mg USD 65  USD65 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Dexamethasone Sodium Phosphate is a glucocorticoid receptor agonist that induces the production of lipocortin, a phospholipase A2 inhibitory protein. Dexamethasone inhibits autophagy levels in damaged cells in a dose-dependent manner. It can be used to construct models of allergic conjunctivitis. Dexamethasone Sodium Phosphate is an interleukin receptor inhibitor and also suppresses COX-2.

Chemical Information
Molecular Weight 516.4
Formula C22H30FO8P.2Na
CAS Number 55203-24-2
Solubility (25°C) Water 100 mg/mL (ultrasonic)
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kamran Hosseini, et al. Pharmacokinetic study of dexamethasone disodium phosphate using intravitreal, subconjunctival, and intravenous delivery routes in rabbits

[2] Kim JB, et al. Brain Res. Dexamethasone inhibits proliferation of adult hippocampal neurogenesis in vivo and in vitro.

[3] Yamamoto K, et al. FEBS Lett. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid.

[4] Blanco FJ, et al. J Rheumatol. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes.

Related Animal Modeling Products
Astragalus Polysacharin (70%)

Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes.

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin.

PLP (139-151)

PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

G6PI 325-339 (human)

G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice.

Heparin sodium salt (MW 15kDa)

Heparin sodium salt (MW 15kDa) is a heparin polymer with a molecular weight of 15kDa.Heparin sodium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII), thereby accelerating the rate of inactivation of Thrombin factor IIa and factor Xa by ATIII. Heparin sodium salt is used for blood collection and plasma preparation in experimental animals and for the construction of parenteral nutrition models in mice.

  Catalog
Abmole Inhibitor Catalog




Keywords: Dexamethasone Sodium Phosphate, Dexamethasone phosphate disodium supplier, Animal Modeling, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.