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Torin 1

Cat. No. M2276
Torin 1 Structure
Size Price Availability Quantity
5mg USD 72  USD72 In stock
10mg USD 115  USD115 In stock
25mg USD 220  USD220 In stock
50mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM. Torin 1 shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1 induces autophagy in HeLa cells. Torin 1 is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice. In a recent study, it is reported Torin 1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.

Product Citations
Chemical Information
Molecular Weight 607.62
Formula C35H28F3N5O2
CAS Number 1222998-36-8
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peterson TR, et al. Cell. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

[2] Li J, et al. Am J Physiol Cell Physiol. mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.

[3] Dowling RJ, et al. Science. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.

[4] Thoreen CC, et al. J Biol Chem. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

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