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mTOR Mammalian Target Of Rapamycin

Inhibitors

Cat.No.  Name Information
M1768 Rapamycin Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M3722 Temsirolimus Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M1666 AZD8055 AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2151 INK128 (Sapanisertib) INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM.
M1709 Everolimus Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM.
M11005 NV-5138 NV-5138, a leucine analogue, is the first selective, orally active intra-brain mTORC1 agonist in combination with Sestrin2. NV-5138 can be used in biological studies of antidepressants.
M10471 MTI-31 (LXI-15029) MTI-31 (LXI-15029) is a novel low-toxicity mTORC1/mTORC2 inhibitor, demonstrated a potent mTOR binding affinity with >5000 fold selectivity over the related PI3K family isoforms. MTI-31 inhibited mTORC1- and mTORC2 function at ≤120 nM in cellular assays.
M10271 mTOR inhibitor-1 mTOR inhibitor-1 is a potential ATP-competitive inhibitor of mTOR which could inhibit cell growth and proliferation.
M10032 L-Leucine L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
M9121 LY303511 hydrochloride LY303511 hydrochloride is a structural analogue of LY294002. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors.
M9050 MHY1485 MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
M7563 CZ415 CZ415 is a potent ATP-competitive mTOR inhibitor with very good cell permeability.
M6226 GNE-477 GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
M6130 Zotarolimus Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.
M4934 Onatasertib (CC-223) Onatasertib (CC-223) is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM).
M4852 LY303511 LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC.
M3722 Temsirolimus Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M3556 WYE-125132 WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
M2299 AZD2014 AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.
M2276 Torin 1 Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively.
M2151 INK128 (Sapanisertib) INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM.
M2118 XL388 XL388 is a novel, highly potent, ATP-competitive and orally bioavailable mTOR inhibitor.
M2099 OSI-027 OSI-027 is an orally bioavailable, potent and selective inhibitor of mTORC1 and mTORC2 with IC50 values of 22 nM and 65 nM, respectively.
M2094 GDC-0349 GDC-0349 is a potent and selective, ATP-competitive mTOR inhibitor.
M2022 Torin 2 Torin 2 is a potent and selective mTOR inhibitor with IC50 of 2.1 nM.



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