mTOR Mammalian Target Of Rapamycin

Inhibitors

Cat.No.	Name	Information
M1768	Rapamycin	Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M3722	Temsirolimus	Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M1666	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2151	INK128 (Sapanisertib)	INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM.
M1709	Everolimus	Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM.
M21167	RMC-5552	The selective mTORC1 complex inhibitor RMC-4529 is a bidentate inhibitor that has a rapamycin-derived, FKBP12-induced heterologous mTOR inhibitor covalently linked to an active-site (orthologous) inhibitor.
M14843	PQR620	PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2.
M14842	mTOR inhibitor-3	mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.
M11541	JR-AB2-011	Jr-ab2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. Jr-ab2-011 inhibited mTORC2 activity by blocking the Rictor-MTOR complex (Ki: 0.19 μM). Jr-ab2-011 has anti-glioblastoma multiforme (GBM) activity.
M11005	NV-5138	NV-5138, a leucine analogue, is the first selective, orally active intra-brain mTORC1 agonist in combination with Sestrin2. NV-5138 can be used in biological studies of antidepressants.
M10471	MTI-31 (LXI-15029)	MTI-31 (LXI-15029) is a novel low-toxicity mTORC1/mTORC2 inhibitor, demonstrated a potent mTOR binding affinity with >5000 fold selectivity over the related PI3K family isoforms. MTI-31 inhibited mTORC1- and mTORC2 function at ≤120 nM in cellular assays.
M10271	mTOR inhibitor-1	mTOR inhibitor-1 is a potential ATP-competitive inhibitor of mTOR which could inhibit cell growth and proliferation.
M10032	L-Leucine	L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
M9121	LY303511 hydrochloride	LY303511 hydrochloride is a structural analogue of LY294002. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors.
M9050	MHY1485	MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
M7563	CZ415	CZ415 is a potent ATP-competitive mTOR inhibitor with very good cell permeability.
M6226	GNE-477	GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
M6130	Zotarolimus	Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.
M4934	Onatasertib (CC-223)	Onatasertib (CC-223) is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM).
M4852	LY303511	LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC.
M3722	Temsirolimus	Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M3556	WYE-125132	WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
M2299	AZD2014	AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.
M2276	Torin 1	Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively.
M2151	INK128 (Sapanisertib)	INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM.

Signaling Pathways

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mTOR Mammalian Target Of Rapamycin

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