Inhibitors
Cat.No. | Name | Information |
---|---|---|
M1768 | Rapamycin | Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. |
M3722 | Temsirolimus | Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM. |
M1666 | AZD8055 | AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM. |
M2151 | INK128 (Sapanisertib) | INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM. |
M1709 | Everolimus | Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM. |
M11005 | NV-5138 | NV-5138, a leucine analogue, is the first selective, orally active intra-brain mTORC1 agonist in combination with Sestrin2. NV-5138 can be used in biological studies of antidepressants. |
M10471 | MTI-31 (LXI-15029) | MTI-31 (LXI-15029) is a novel low-toxicity mTORC1/mTORC2 inhibitor, demonstrated a potent mTOR binding affinity with >5000 fold selectivity over the related PI3K family isoforms. MTI-31 inhibited mTORC1- and mTORC2 function at ≤120 nM in cellular assays. |
M10271 | mTOR inhibitor-1 | mTOR inhibitor-1 is a potential ATP-competitive inhibitor of mTOR which could inhibit cell growth and proliferation. |
M10032 | L-Leucine | L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway. |
M9121 | LY303511 hydrochloride | LY303511 hydrochloride is a structural analogue of LY294002. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. |
M9050 | MHY1485 | MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes. |
M7563 | CZ415 | CZ415 is a potent ATP-competitive mTOR inhibitor with very good cell permeability. |
M6226 | GNE-477 | GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor. |
M6130 | Zotarolimus | Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM. |
M4934 | Onatasertib (CC-223) | Onatasertib (CC-223) is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM). |
M4852 | LY303511 | LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC. |
M3722 | Temsirolimus | Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM. |
M3556 | WYE-125132 | WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR. |
M2299 | AZD2014 | AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity. |
M2276 | Torin 1 | Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively. |
M2151 | INK128 (Sapanisertib) | INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM. |
M2118 | XL388 | XL388 is a novel, highly potent, ATP-competitive and orally bioavailable mTOR inhibitor. |
M2099 | OSI-027 | OSI-027 is an orally bioavailable, potent and selective inhibitor of mTORC1 and mTORC2 with IC50 values of 22 nM and 65 nM, respectively. |
M2094 | GDC-0349 | GDC-0349 is a potent and selective, ATP-competitive mTOR inhibitor. |
M2022 | Torin 2 | Torin 2 is a potent and selective mTOR inhibitor with IC50 of 2.1 nM. |
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