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RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity.
| Molecular Weight | 1784.14 |
| Formula | C91H138N12O24 |
| CAS Number | 1887095-82-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 178 mg/mL (Need ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
[1] Kevin Lou, et al. Science. IFITM proteins assist cellular uptake of diverse linked chemotypes
[2] Ziyang Zhang, et al. Nature. Brain-restricted mTOR inhibition with binary pharmacology
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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