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JR-AB2-011

Cat. No. M11541
JR-AB2-011  Structure
Size Price Availability
5mg USD 208  USD260 Out of stock
10mg USD 352  USD440 Out of stock
25mg USD 752  USD940 Out of stock
50mg USD 1280  USD1600 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Jr-ab2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. Jr-ab2-011 inhibited mTORC2 activity by blocking the Rictor-MTOR complex (Ki: 0.19 μM). Jr-ab2-011 has anti-glioblastoma multiforme (GBM) activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 398.28
Formula C17H14Cl2FN3OS
CAS Number 2411853-34-2
Purity >98%
Solubility DMSO ≥ 40 mg/mL
Storage 4°C , protect from light , dry , sealed
References

[1] Angelica Benavides-Serrato, et al. PLoS One . Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

[2] Mei-Mei Wu, et al. Pharmacol Res. Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization

[3] Jessica Guenzle, et al. Int J Mol Sci. Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma

[4] Angelica Benavides-Serrato, et al. PLoS One. Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

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Keywords: JR-AB2-011 supplier, mTOR, inhibitors

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