JR-AB2-011

Cat. No. M11541

All AbMole products are for research use only, cannot be used for human consumption.

Size	Price	Availability
5mg	USD 260 USD260	Out of stock
10mg	USD 440 USD440	Out of stock
25mg	USD 800 USD800	Out of stock

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Quality Control & Documentation

Purity: >98%
COA
MSDS

Product Information

Biological Activity

Jr-ab2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. Jr-ab2-011 inhibited mTORC2 activity by blocking the Rictor-MTOR complex (Ki: 0.19 μM). Jr-ab2-011 has anti-glioblastoma multiforme (GBM) activity.

Chemical Information

Molecular Weight	398.28
Formula	C17H14Cl2FN3OS
CAS Number	2411853-34-2
Solubility (25°C)	DMSO ≥ 40 mg/mL
Storage	4°C, protect from light, dry, sealed

References

[1] Angelica Benavides-Serrato, et al. PLoS One . Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

[2] Mei-Mei Wu, et al. Pharmacol Res. Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization

[3] Jessica Guenzle, et al. Int J Mol Sci. Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma

[4] Angelica Benavides-Serrato, et al. PLoS One. Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma

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JR-AB2-011

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